Motif ID: DMAP1_NCOR{1,2}_SMARC.p2

Z-value: 1.574


Transcription factors associated with DMAP1_NCOR{1,2}_SMARC.p2:

Gene SymbolEntrez IDGene Name
DMAP1 55929 DNA methyltransferase 1 associated protein 1
NCOR1 9611 nuclear receptor co-repressor 1
NCOR2 9612 nuclear receptor co-repressor 2
SMARCA1 6594 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMARCA5 8467 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCC2 6601 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMARCA1chrX_-_128485062-0.674.7e-03Click!
SMARCA5chr4_+_1446540050.621.0e-02Click!
SMARCC2chr12_-_548695680.621.1e-02Click!
NCOR1chr17_-_160595140.282.9e-01Click!
NCOR2chr12_-_1236179620.126.7e-01Click!


Activity profile for motif DMAP1_NCOR{1,2}_SMARC.p2.

activity profile for motif DMAP1_NCOR{1,2}_SMARC.p2


Sorted Z-values histogram for motif DMAP1_NCOR{1,2}_SMARC.p2

Sorted Z-values for motif DMAP1_NCOR{1,2}_SMARC.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of DMAP1_NCOR{1,2}_SMARC.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_26665213 4.115 EVI2B
ecotropic viral integration site 2B
chr19_-_44518516 3.078 NM_004877
GMFG
glia maturation factor, gamma
chr2_+_143603439 3.069 ARHGAP15
Rho GTPase activating protein 15
chrX_+_78087484 3.011 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr2_+_143603368 3.006 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr1_-_149004916 2.961 NM_004079
CTSS
cathepsin S
chr19_-_44518465 2.850 GMFG
glia maturation factor, gamma
chr12_-_15005761 2.805 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_+_196874839 2.574 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_32512298 2.480 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr14_-_106184988 2.369 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_73826244 2.357 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr5_-_149772469 2.339 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr5_-_94442941 2.280 MCTP1
multiple C2 domains, transmembrane 1
chr15_+_86983038 2.245 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr20_+_44180296 2.239 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr17_-_26665144 2.214 EVI2B
ecotropic viral integration site 2B
chr14_+_75058518 2.149 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr1_-_149004879 2.101 CTSS
cathepsin S
chr5_-_138753443 2.097 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr14_+_75058591 2.020 BATF
basic leucine zipper transcription factor, ATF-like
chr3_+_120799411 2.018 NM_015900
PLA1A
phospholipase A1 member A
chr1_+_196874759 2.000 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_-_149004852 1.967 CTSS
cathepsin S
chr5_-_169657312 1.937 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_-_26665220 1.857 NM_006495
EVI2B
ecotropic viral integration site 2B
chr14_-_106270497 1.779 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr20_+_44180355 1.767 CD40
CD40 molecule, TNF receptor superfamily member 5
chr17_-_59437782 1.716 NM_000873
ICAM2
intercellular adhesion molecule 2
chr6_-_33016561 1.708 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr17_-_26665194 1.708 EVI2B
ecotropic viral integration site 2B
chr5_-_169657395 1.693 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chrX_+_37524190 1.675 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr12_+_25096472 1.629 NM_006152
LRMP
lymphoid-restricted membrane protein
chr13_-_45654327 1.616 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_-_149772563 1.521 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr5_-_169657360 1.482 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_94443300 1.477 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr12_+_11694172 1.465 ETV6
ets variant 6
chr4_+_39874921 1.459 NM_004310
RHOH
ras homolog gene family, member H
chr17_-_31231421 1.449 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr22_+_38652555 1.443 GRAP2
GRB2-related adaptor protein 2
chr10_-_14412813 1.388 NM_018027
FRMD4A
FERM domain containing 4A
chr16_+_11966464 1.383 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_+_938709 1.382 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr19_-_17377383 1.369 NM_004335
BST2
bone marrow stromal cell antigen 2
chr6_+_31647854 1.286 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_+_32489426 1.263 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr8_-_102872372 1.246 NCALD
neurocalcin delta
chr3_+_123279439 1.222 NM_006889
CD86
CD86 molecule
chr16_-_4836198 1.206 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr14_-_22358752 1.172 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr8_-_102872354 1.167 NCALD
neurocalcin delta
chrX_-_30505804 1.166 NM_025159
CXorf21
chromosome X open reading frame 21
chr10_-_11614279 1.165 NM_001080491
USP6NL
USP6 N-terminal like
chr11_+_303852 1.123 NM_003641
IFITM1
interferon induced transmembrane protein 1 (9-27)
chr1_+_100957883 1.120 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr1_-_205161821 1.106 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr1_-_149586298 1.076 RFX5
regulatory factor X, 5 (influences HLA class II expression)
chrX_+_37524250 1.059 CYBB
cytochrome b-245, beta polypeptide
chr1_+_78888064 1.055 NM_006417
IFI44
interferon-induced protein 44
chr1_+_165564904 1.052 NM_001198783
POU2F1
POU class 2 homeobox 1
chr14_+_99601498 1.026 NM_016337
EVL
Enah/Vasp-like
chr14_+_99601517 1.004 EVL
Enah/Vasp-like
chr19_-_53450953 0.998 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr13_+_42034871 0.969 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr5_-_169657192 0.958 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_+_128068982 0.902 NM_002017
FLI1
Friend leukemia virus integration 1
chr17_-_31441390 0.886 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr22_+_38627031 0.859 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr1_+_165565006 0.852 POU2F1
POU class 2 homeobox 1
chr1_-_9052253 0.845 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr17_+_64922420 0.820 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr17_-_78000890 0.802 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr2_-_213723298 0.792 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr11_+_5602782 0.791 NM_021616
TRIM34
tripartite motif containing 34
chr12_+_11693909 0.791 ETV6
ets variant 6
chr13_-_45654296 0.777 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_40925151 0.774 NM_024660
TMEM149
transmembrane protein 149
chr17_+_6600080 0.765 XAF1
XIAP associated factor 1
chr7_-_115458064 0.763 TFEC
transcription factor EC
chr7_-_115458010 0.757 NM_001018058
NM_012252
TFEC

transcription factor EC

chr1_-_9052170 0.754 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr1_-_149586341 0.752 NM_000449
NM_001025603
RFX5

regulatory factor X, 5 (influences HLA class II expression)

chr1_+_32438788 0.750 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr12_-_47604930 0.724 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr12_+_25096755 0.718 LRMP
lymphoid-restricted membrane protein
chr4_+_147316284 0.715 NM_007080
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr10_+_35466715 0.714 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr3_-_49826221 0.711 UBA7
ubiquitin-like modifier activating enzyme 7
chr8_-_102872614 0.695 NM_032041
NCALD
neurocalcin delta
chr12_-_51887318 0.693 ITGB7
integrin, beta 7
chr17_+_75849221 0.687 NM_020914
NM_020954
RNF213

ring finger protein 213

chr14_+_63750611 0.675 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr3_-_58175437 0.663 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr2_-_191587153 0.660 STAT1
signal transducer and activator of transcription 1, 91kDa
chr15_+_72687765 0.658 NM_003992
CLK3
CDC-like kinase 3
chr8_+_26206648 0.647 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr20_-_51633042 0.637 NM_006526
ZNF217
zinc finger protein 217
chr12_-_47605478 0.635 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chrX_-_131401319 0.633 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr1_+_196874867 0.627 PTPRC
protein tyrosine phosphatase, receptor type, C
chr3_+_134601479 0.625 NM_003571
BFSP2
beaded filament structural protein 2, phakinin
chr8_+_142501188 0.618 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr6_+_138230045 0.606 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr3_+_188568861 0.602 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr6_+_29799182 0.602 HLA-F
major histocompatibility complex, class I, F
chr4_-_71751070 0.600 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr22_+_38627129 0.600 GRAP2
GRB2-related adaptor protein 2
chr4_-_38482805 0.593 NM_003263
TLR1
toll-like receptor 1
chr18_-_49944986 0.591 MBD2
methyl-CpG binding domain protein 2
chr10_-_123724251 0.588 NSMCE4A
non-SMC element 4 homolog A (S. cerevisiae)
chr19_-_52308848 0.574 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr1_+_173111306 0.570 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr12_-_51887266 0.568 NM_000889
ITGB7
integrin, beta 7
chr5_+_102493155 0.555 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr21_-_14840506 0.554 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr1_+_51207242 0.549 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr20_-_23010786 0.547 CD93
CD93 molecule
chr18_+_13601664 0.541 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr11_+_5667494 0.526 NM_006074
TRIM22
tripartite motif containing 22
chr17_-_44043361 0.522 NM_004502
HOXB7
homeobox B7
chr11_-_47502115 0.521 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr7_+_119700924 0.520 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr9_+_2707525 0.514 NM_133497
KCNV2
potassium channel, subfamily V, member 2
chr17_+_6599879 0.512 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr5_+_162820094 0.511 NM_001142556
NM_001142557
NM_012484
NM_012485
HMMR



hyaluronan-mediated motility receptor (RHAMM)



chr13_-_71338558 0.500 DACH1
dachshund homolog 1 (Drosophila)
chr12_+_121577733 0.498 NM_014708
KNTC1
kinetochore associated 1
chr17_-_44042924 0.492 HOXB7
homeobox B7
chr13_-_71338144 0.492 DACH1
dachshund homolog 1 (Drosophila)
chr9_-_5294579 0.491 NM_005059
NM_134441
RLN2

relaxin 2

chr5_-_88155360 0.489 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_-_191587127 0.485 STAT1
signal transducer and activator of transcription 1, 91kDa
chr6_+_64403668 0.483 PHF3
PHD finger protein 3
chr17_-_45196465 0.483 FAM117A
family with sequence similarity 117, member A
chr22_-_22252376 0.481 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr1_-_9052207 0.473 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr21_+_41714311 0.470 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr10_-_123724631 0.469


chr10_-_123724698 0.468 NM_001167865
NM_017615
NSMCE4A

non-SMC element 4 homolog A (S. cerevisiae)

chr1_+_178190493 0.467 NM_014810
CEP350
centrosomal protein 350kDa
chr12_-_119038941 0.462 RAB35
RAB35, member RAS oncogene family
chr5_-_176671437 0.450 MXD3
MAX dimerization protein 3
chr11_+_9552809 0.450 NM_001143976
WEE1
WEE1 homolog (S. pombe)
chrX_-_135783496 0.449


chrX_-_135690699 0.448 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr6_+_26473376 0.446 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr3_+_153468518 0.442 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr8_+_17866373 0.441 PCM1
pericentriolar material 1
chr6_+_110608284 0.440 NM_015891
CDC40
cell division cycle 40 homolog (S. cerevisiae)
chr3_+_63928459 0.434 NM_001128149
ATXN7
ataxin 7
chr10_-_99042419 0.434 ARHGAP19
Rho GTPase activating protein 19
chr2_-_162883062 0.428 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr11_-_88864061 0.428 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr17_-_37518213 0.428 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr1_+_239762179 0.427 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr14_+_75687997 0.425 NM_017926
NM_017972
C14orf118

chromosome 14 open reading frame 118

chr1_-_25164061 0.424 NM_001031680
RUNX3
runt-related transcription factor 3
chrX_-_135690770 0.424 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_159099090 0.420 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr17_-_44043278 0.420 HOXB7
homeobox B7
chr7_+_149696792 0.418 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr1_-_161439248 0.417 NM_001195303
RGS5
regulator of G-protein signaling 5
chr17_-_64649608 0.415 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr14_+_69307914 0.413 SRSF5
serine/arginine-rich splicing factor 5
chr19_-_55104875 0.412 NUP62
nucleoporin 62kDa
chr14_+_75688042 0.410 C14orf118
chromosome 14 open reading frame 118
chr12_+_11693993 0.408 NM_001987
ETV6
ets variant 6
chr13_-_46368968 0.401 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr6_+_12825818 0.400 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr6_-_74284522 0.399 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr11_+_116555048 0.398 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr5_-_54317102 0.395 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr1_+_157441824 0.393 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr20_+_30409649 0.391 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr3_+_48482625 0.387 TREX1
three prime repair exonuclease 1
chr13_-_45654292 0.384 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_47468029 0.382 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr2_-_171796069 0.382 NM_001136554
TLK1
tousled-like kinase 1
chr16_+_27346079 0.381 NM_021798
IL21R
interleukin 21 receptor
chr6_-_24827265 0.379 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr1_+_40977092 0.378 NFYC
nuclear transcription factor Y, gamma
chr14_-_105796268 0.376 ZCWPW2
IGHV3-23
IGKV3-20
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
chr7_-_99536929 0.375 MCM7
minichromosome maintenance complex component 7
chr10_+_28918672 0.374 WAC
WW domain containing adaptor with coiled-coil
chr18_+_71051713 0.373 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr8_-_124477846 0.373 ATAD2
ATPase family, AAA domain containing 2
chr21_+_42792810 0.372 NM_018964
SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr17_-_39094787 0.372 NM_001040002
MEOX1
mesenchyme homeobox 1
chr9_+_127550298 0.370 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr2_-_152538694 0.369 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr13_-_25687062 0.369 RNF6
ring finger protein (C3H2C3 type) 6
chrX_-_80344096 0.368 NM_030763
HMGN5
high-mobility group nucleosome binding domain 5
chr6_+_43089908 0.366 KLHDC3
kelch domain containing 3
chr12_-_22588352 0.364 KIAA0528
KIAA0528
chr1_-_33275071 0.363 NM_013411
AK2
adenylate kinase 2
chr2_-_160181206 0.363 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr7_+_28418668 0.362 NM_182898
CREB5
cAMP responsive element binding protein 5
chr10_+_91051685 0.362 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.04 1.51e-07 GO:0006955 immune response
1.78 1.86e-07 GO:0002376 immune system process
4.59 2.31e-05 GO:0034340 response to type I interferon
4.42 1.09e-04 GO:0060337 type I interferon-mediated signaling pathway
4.42 1.09e-04 GO:0071357 cellular response to type I interferon
2.23 3.61e-04 GO:0045087 innate immune response
2.65 1.08e-03 GO:0019221 cytokine-mediated signaling pathway
2.57 4.93e-03 GO:0046649 lymphocyte activation
2.34 8.41e-03 GO:0045321 leukocyte activation
2.39 1.05e-02 GO:0071345 cellular response to cytokine stimulus
1.63 4.86e-02 GO:0006952 defense response
2.05 4.99e-02 GO:0034097 response to cytokine stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 3.59e-03 GO:0005634 nucleus
1.39 8.00e-03 GO:0031981 nuclear lumen
1.35 9.38e-03 GO:0044428 nuclear part
1.45 1.31e-02 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.31 4.12e-03 GO:0003676 nucleic acid binding
1.14 1.81e-02 GO:0005515 protein binding
1.34 2.63e-02 GO:0003677 DNA binding